Products Technologies Imaging Mass Cytometry

Imaging Mass Cytometry

Imaging Mass Cytometry™ (IMC™) is the most trusted technology that enables researchers to accurately assess complex phenotypes and immune spatial interactions in the tissue microenvironment.

Explore mechanism of action, disease progression and therapeutic outcomes – with confidence.

Keep current with how IMC is used to gain deep spatial insights – see articles, news, publications, bibliographies, tips and more on our IMC Trending Topics page.

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Discover the throughput and precision that is uniquely designed for translational researchers.

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Imaging Mass Cytometry generates high-dimensional spatial data at subcellular resolution. IMC uses cytometry by time-of-flight (on which CyTOF® systems are based) to overcome the multiplexing limitations of traditional immunohistochemistry (IHC) and immunofluorescence. By applying metal-tagged antibodies instead of fluorochromes, IMC has the unique capability to simultaneously stain, acquire and analyze 40-plus markers of interest on a tissue section without interference from autofluorescent tissues or management of spectral overlap.

IMC is the only technology with


No autofluorescence interference to image any tissue type
40-plus markers imaged simultaneously to get results faster
Protein and RNA co-detection for deeper insights
Integrated cell segmentation for faster interpretation
Batch staining of all slides for high-volume studies
Dual imaging and flow cytometry mode to maximize investment

IMC shows the true biology

High-plex imaging for all tissue types ― including lung, bone marrow, colon and brain ― without autofluorescence interference.

  • Well-defined red signals from CD68
  • Cellular structure is sharply defined by yellow pan-cytokeratin stain
 

  • CD68 indistinct or missing
  • Cellular structure diffuse

 

Reasons to choose IMC for your high-plex imaging study


WORKFLOW

Get results faster


Hyperion™ Imaging Systems use a one-step staining and detection approach that enables samples to be simultaneously stained, acquired and analyzed.

1

Modularized panels

Swap markers without panel revalidation.

2

Simultaneous staining

Stain 40-plus markers for all slides at once.

3

One-step detection

Simultaneous imaging of 40-plus markers, including protein and RNA.

4

Precise signals

Image any tissue without autofluorescence.

5

Real-time analysis

Visualize 40-plus markers in 30 minutes.

A one-step staining and detection workflow


Imaging Mass Cytometry enables 40-plus markers that can be simultaneously stained, acquired and visualized. Other fluorescence-based approaches involve iterative rounds of staining, imaging and removal of fluorescent signals. The IMC workflow is without sequential immunostaining approaches, multiple slide treatment rounds or acquisition steps.

Need to ship or store slides?


  • All-at-once batch staining of all slides to reduce technical variation
  • Acquire at any time from shipped and/or stored slides that have been stained
  • Analyze previously banked tissue slides to be correlated to known clinical outcomes

A workflow ideal for high-volume samples,
clinical research trials and multi-site studies

 

Events

Join us for one of our upcoming events or watch on demand.

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Mar 06 - Mar 09

Location

50th ADF Conference (Dermatological Research Working Group) in Duesseldorf, Germany

Mar 09 - Mar 13

Location

US HUPO 2024 (Human Proteome Organization) in Portland, OR

Mar 12 - Mar 13

Location

1st German FlowCore Summit in Mainz, Germany

Mar 13 - Mar 15

Location

Antimicrobial Resistance – Genomes, Big Data and Emerging Technologies in Hinxton, UK

Mar 13 - Mar 16

Location

18th WRIM (World Immune Regulation Meeting) in Davos, Switzerland

Mar 14 - Mar 15

Location

BSI (British Society for Immunology) Revealing and tackling the complexities of the tumour microenvironment in Birmingham, UK

Mar 18 - Mar 19

Location

Spatial Biology UK 2024 in London, UK

Mar 19 - Mar 21

Location

German Plant Breeding Conference 2024 in Geisenheim, Germany

Mar 21 - Mar 23

Location

10th iTOC (Immunotherapy of Cancer) Conference in Munich, Germany

Mar 24 - Mar 26

Location

CROP Innovation and Business in Ghent, Belgium

Unless explicitly and expressly stated otherwise, all products are provided for Research Use Only, not for use in diagnostic procedures. Find more information here.