Unique spatial landscapes and comprehensive phenotypic analysis bring insight
Understanding the presence and location of stromal, tumor and immune cells and how they interact in the tissue or tumor microenvironment is key to obtaining new insights into disease pathophysiology and therapeutic response. The features listed below demonstrate how rich Imaging Mass Cytometry™ (IMC™) data has been used to harness the power of high-plex imaging to explore tissue structure, function and phenotype at the single-cell level.
Revealing heterogeneity of inflammatory bowel disease (IBD)
A team led by Klaus Kaestner, PhD, in the Department of Genetics at the University of Pennsylvania Perelman School of Medicine developed a panel that can be used to quantify the heterogeneous nature of IBD and how immune cells interact within the spatial environment of this disease. Learn how expansive characterization using IMC helps close gaps in knowledge about diseases.
Uncovering COVID-19 lung pathology
Weill Cornell Medicine scientists recently accomplished an important step forward in understanding lung pathology and immune response to COVID-19 in the Nature publication “The spatial landscape of lung pathology during COVID-19 progression.” Learn how a team led by Olivier Elemento, PhD, Director of the Englander Institute for Precision Medicine and Cornell University Professor of Physiology and Biophysics, was able to view not only the structure of the tissue but also the interplay between infected cells and the immune system in COVID-19 patients.
- Read the Weill Cornell press release.
- Nature Portfolio webcast: Watch the July 13 webcast on demand.
Non-random signaling clusters in glioblastoma
Rebecca Ihrie, PhD, Associate Professor of Cell and Developmental Biology at Vanderbilt University, discusses her glioblastoma research to identify and associate cell-to-cell variation and distribution within different tumors to phenotypes, extending stratification work done using mass cytometry. Ihrie highlights how she has performed high-multiplex analysis in dual-mode capacity, generating data from both tissue samples and cells in suspension using CyTOF® mass cytometry.
Characterization of hepatic adaptive and innate immune sets in hepatitis B virus
Research led by Kyong-Mi Chang, MD, Professor of Medicine (GI) at the University of Pennsylvania Perelman School of Medicine, shows marked correlations between adaptive and innate immune microenvironment with relevance to hepatitis B viral pathogenesis. Learn how the comprehensive phenotypic analysis was performed and correlated with hepatocellular injury, inflammation and fibrosis.
- Read Dr. Kyong-Mi Chang's JCI Insight publication "Highly multiplexed 2-dimensional Imaging Mass Cytometry analysis of HBV-infected liver."
- Watch Nature Portfolio webcast.
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Febe van Maldegem, PhD, and Karishma Valand
Imaging the dramatic remodeling of the lung tumor microenvironment
Melissa Davis, PhD
Defining spatial characteristics using Imaging Mass Cytometry
Bernd Bodenmiller, PhD
Bernd Bodenmiller on revealing new insights into tumors with Imaging Mass Cytometry
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