Anti-Mouse CD11b (M1/70)-143Nd—100 Tests

CD11b, also known as Mac-1, is a transmembrane glycoprotein known to be involved in cell adhesion and phagocytosis. CD11b is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, dendritic cells, and natural killer cells.

Anti-Human CD52 (HI186)-146Nd—100 Tests

The HI186 monoclonal antibody specifically binds to CD52, a 25–29 kDa glycoprotein also known as Cambridge pathology 1 antigen (CAMPATH-1) or human epididymis-specific protein 5 (HE5). CD52 is N-glycosylated, and its C-terminus is glycophosphatidylinositol-anchored in the membrane. It is highly expressed on the surface of thymocytes, mature lymphocytes, monocytes, dendritic cells, eosinophils, and epithelial cells of the epididymis and seminal vesicles. Neutrophils, plasma cells, platelets, and erythrocytes lack expression of CD52. The functional role of CD52 is not well-characterized. However, anti-CD52 antibodies have been employed clinically to remove lymphocytes from transplanted bone marrow.

Anti-Human TCRa/b (IP26)-176Yb—100 Tests

The IP26 antibody reacts specifically with the α/β T cell receptor, which is expressed on greater than 95% of normal peripheral blood CD3+ T cells. The α/β T cell antigen receptor (TCR) recognizes a peptide bound to the MHC. The TCR recognizes foreign antigens and translates such recognition events into intracellular signals, which lead to T cell activation. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on both T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins, and T cytotoxic cells display CD8.

Anti-Human CD61 (VI-PL2)-146Nd—100 Tests

CD61, also known as integrin b3 or glycoprotein IIIa (GPIIIa), is a type I transmembrane glycoprotein. CD41 is a member of the integrin family and is expressed on platelets and megakaryocytes playing a role in platelet activation and aggregation. CD61 in complex with CD51 has also been reported on osteoclasts, fibroblasts, macrophages, and some tumor cells.

Anti-Human TdT (E17-1519)-164Dy—100 Tests

Terminal deoxynucleotidyl transferase (TdT) is a 60 kDa terminal tranferase, a specialized DNA polymerase that adds N nucleotides to the V, D, and J exons during antibody and T cell receptor gene recombination. TdT is expressed in the nucleus of pre-B and pre-T cells in addition to acute lymphoblastic leukemic cells. Mature lymphocytes from normal peripheral blood usually do not express the enzyme. TdT catalyzes the addition of nucleotides to the 3' terminus of a DNA molecule.

Anti-Mouse CD185/CXCR5 (L138D7)-142Nd—100 Tests

CXCR5, also known as CD185 and Burkitt's lymphoma receptor 1 (BLR1), is a chemokine receptor that binds to CXCL13. CXCR5 plays an essential role in the migration of B cells to the follicular compartment in the spleen, lymph nodes, Peyer's patches, and tonsils. It also plays a role in normal maturation of primary follicle follicular dendritic cells. CXCR5 is expressed on B cells and TFH cells.

Anti-Human CD11c (3.9)-146Nd—100 Tests

CD11c is a transmembrane glycoprotein also known as integrin αX or CR4. CD11c is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. It has also been associated with hairy cell leukemias, acute nonlymphocytic leukemias, and some B cell chronic lymphocytic leukemias.

Anti-Human CD55 (JS11)-148Nd—100 Tests

The JS11 monoclonal antibody specifically binds to CD55, a 60–70 kDa glycosylphosphatidylinositol (GPI)-anchored single-chain glycoprotein that is also known as decay-accelerating factor (DAF). CD55 is expressed on all cells in contact with serum, including all hematopoietic cells and vascular endothelium. CD55 can also exist in a soluble form, which is present in plasma. CD55 is thought to contribute to the protection of cells from the damage by autologous complement through inhibition of the amplification steps of the complement cascade. There is also evidence that CD55 interacts with CD97 and can bind to coxsackie and echovirus.

Anti-Human CD172b (B4B6)-149Sm—100 Tests

CD172b, also known as signal-regulatory protein β (SIRPβ), is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. It contains a single-pass transmembrane region with immunoglobulin-like domains. Unlike CD172a, this receptor lacks a cytoplasmic SHP-2 binding domain. CD172b is expressed on cells of monocyte, macrophage or dendritic lineages. CD172a and CD172b are based on the putative structures of their C-terminal intracellular domains, which distinguish them as either activating (CD172b) or inhibitory (CD172a) isoforms. They have complementary roles in signal regulation and may work together in tuning the response to a stimulus.

Anti-Human IgD (IA6-2)-146Nd—100 Tests

Immunoglobulin D (IgD) is an antibody isotype that accounts for ~1% of proteins in the plasma membranes of peripheral immature B lymphocytes. It is usually co-expressed with membrane IgM and serves as a B cell receptor for antigen (BCR). The IA6-2 monoclonal antibody binds to the heavy chain of human IgD.