APPLICATION NOTE
Unraveling Metabolic Reprogramming in Cancer with Spatial Proteomics
Modular Imaging Mass Cytometry™ panels identify metabolic states of tumor and immune cells in the tissue microenvironment
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Read about revolutionary insights into cancer metabolism.
Technical breakthrough: Modular IMC panels
The Human Cell Metabolism IMC Panel targets seven key metabolic markers covering six critical pathways: glucose metabolism, fatty acid oxidation, lactate metabolism, TCA cycle, oxidative phosphorylation and mTOR signaling.
- Spatially resolved metabolic profiling reveals how tumor cells differentially utilize glucose and fatty acid oxidation to fuel growth
- Hot vs. cold tumor identification is based on immune infiltration patterns associated with specific metabolic activities
- Single-cell resolution analysis distinguishes metabolic zones and associates immune cell positioning with tumor metabolic states
- Therapeutic resistance mechanisms are uncovered through comprehensive spatial and metabolic profiling
- Precision oncology applications are enabled by detailed metabolic pathway analysis in tissue microenvironments