SomaSignal Tests

SomaSignal™ Tests turn complex protein data into clear, actionable insights. Whether assessing metabolic, cardiovascular and organ health or revealing how sample handling impacts results, these tests empower researchers to better understand both human biology and pre-analytical variation.

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Biological Health and Sample Integrity

SomaSignal Test

Description

Metabolic and energy balance
Body fat % Percent body fat
Resting energy expenditure Calories burned at rest
Glucose tolerance Blood glucose levels following sugar intake
Fed-fasted Hours since last meal
Lean body mass Total lean body mass
Visceral fat Fat content around vital organs
Cardiovascular health and fitness
CVD primary Four-year risk of heart attack, stroke or heart failure
CVD secondary Four-year risk of heart attack, stroke or heart failure following an initial event
Cardiorespiratory fitness Aerobic fitness level (VO2 max)
Heart failure with reduced ejection fraction: six months Risk of death in six months with stable HFrEF
Heart failure with reduced ejection fraction: 12 months Risk of death in 12 months with stable HFrEF
Heart failure with preserved ejection fraction: six months Risk of death in six months with stable HFpEF
Heart failure with preserved ejection fraction: 12 months Risk of death in 12 months with stable HFpEF
Organ and tissue health
NASH: steatosis Measures NASH-related liver steatosis
NASH: inflammation Measures NASH-related liver inflammation
NASH: fibrosis Measures NASH-related liver fibrosis
NASH: ballooning Measures NASH-related liver ballooning
Liver fat Presence/absence of excess liver fat
Alcohol impact Predicted weekly alcohol consumption
Dementia risk Risk of dementia diagnosis within 20 years
Kidney prognosis Risk of worsening chronic kidney disease
Pre-analytical variation
Time-to-spin Sample variation based on the time between blood collection and centrifugation to separate blood cells from human serum or EDTA plasma
Time-to-decant Sample variation based on the time between blood collection and decanting to separate blood cells from human serum or EDTA plasma
Time-to-freeze Sample variation based on the time between blood collection and freezing human serum or EDTA plasma
Freeze-thaw Sample variation based on the number of times human serum or EDTA plasma is frozen and thawed
Fed-fasted (also relevant to metabolic and energy balance) Sample variation based on whether the study participant was fed or fasted prior to EDTA plasma collection.

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Note: SomaSignal Tests for pre-analytical variation are only available on the SomaScan 7K Assay.

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