on-demand webinar
Single-Cell Signaling Analysis of Tumor Microenvironment Organoids
Insights into how the tumor microenvironment impacts drug response
Discover how patient-derived organoids (PDOs) and CyTOF™ technology are transforming personalized cancer research. In this on-demand webinar, Christopher Tape, PhD, shares groundbreaking insights into how cancer-associated fibroblasts (CAFs) influence colorectal cancer (CRC) therapy outcomes, revealed through advanced single-cell analysis of PDOs.
Whether you’re a cancer biologist, translational researcher or drug discovery scientist, this webinar offers actionable insights into tumor-stroma interactions and therapeutic modeling.
What you'll learn:
- Single-cell multi-omics in action: See how CyTOF technology profiles post-translational modification signaling, DNA damage, cell-cycle activity and apoptosis in 2,500-plus CRC PDOs and CAFs
- The hidden role of CAFs: Explore how CAFs drive plasticity in tumor cells, protecting them from chemotherapy by shifting cell states
- Commonalities in drug response: Learn why even chemorefractory PDOs show common, targetable drug-induced DNA damage and cell-cycle effects
Tape received his PhD from Professor Gillian Murphy's lab at the CRUK Cambridge Institute (University of Cambridge). He was then awarded a Sir Henry Wellcome Postdoctoral Fellowship between the Institute of Cancer Research (with Claus Jorgensen, PhD, and Chris Marshall, DPhil) and the Massachusetts Institute of Technology (with Doug Lauffenburger, PhD). Tape now leads the Cell Communication Lab at University College London Cancer Institute studying how different cell types collaborate to drive cancer.
Single-Cell Signaling Analysis of Tumor Microenvironment Organoids
A presentation by Chris Tape, PhD