b'Detection of pathological tissue compartments in the neurodegenerative brainTissue Mode in combination with neurodegenerative panels allows whole tissue visualization of the main protein contributors to disease pathology: amyloid precursor protein (APP) in amyloid plaques and Tau in tangles of AD (left panel); p-Synuclein (p-Syn) in Lewy bodies and Lewy neurites of PD (middle panel); and large areas of lost myelin in a lesion of MS (right panel).Pixel-clustering analysis reveals extracellular aggregates and distinct morphology clustersIn AD, pixel-clustering analysis unveiled eight distinct morphology clusters, such as gray matter-associated and white matter-associated microglia (combined in one cluster); three distinct populations of neurons, fibrous and protoplasmic astrocytes (combined in one cluster); oligodendrocytes; and vasculature, alongside the identification of two functional amyloid aggregate clusters. The arrangement of APP and Tau hints at a potential aggregate stabilization and overall synergy among those proteins, alongside Syn, all known to be prone to misfolding in the diseased brain. A 41-marker panel, comprised of disease-specific neurodegenerative subpanels, was designed to study diseased brain tissue.Human Immuno-Oncology IMC Panel, 3 1 Antibodies (PN 201509) Maxpar NeuroParkinsonsMaxpar Cell FunctionalStromalBasicLymphoidMyeloid Basic TissuePhenotypingDiseaseIMC Cell State Cell Immune PN 201512 PN 201513 Architecture7 Antibodies PN 9100006 Segmentation Kit PN 201514 PN 201511 PN 201518 PN 201517 PN 201337 AlzheimersPN 201500Disease PN 9100007Multiple Sclerosis PN 9100008'