Imaging Mass Cytometry
Imaging Mass Cytometry™ (IMC™) is the most trusted technology that enables researchers to accurately assess complex phenotypes and immune spatial interactions in the tissue microenvironment.
Explore mechanism of action, disease progression and therapeutic outcomes – with confidence.
Keep current with how IMC is used to gain deep spatial insights – see articles, news, publications, bibliographies, tips and more on our IMC Trending Topics page.
Imaging Mass Cytometry generates high-dimensional spatial data at subcellular resolution. IMC uses cytometry by time-of-flight (on which CyTOF® systems are based) to overcome the multiplexing limitations of traditional immunohistochemistry (IHC) and immunofluorescence. By applying metal-tagged antibodies instead of fluorochromes, IMC has the unique capability to simultaneously stain, acquire and analyze 40-plus markers of interest on a tissue section without interference from autofluorescent tissues or management of spectral overlap.
IMC is the only technology with
No autofluorescence interference to image any tissue type
40-plus markers imaged simultaneously to get results faster
Protein and RNA co-detection for deeper insights
Integrated cell segmentation for faster interpretation
Batch staining of all slides for high-volume studies
Dual imaging and flow cytometry mode to maximize investment
IMC shows the true biology
High-plex imaging for all tissue types ― including lung, bone marrow, colon and brain ― without autofluorescence interference.
- Well-defined red signals from CD68
- Cellular structure is sharply defined by yellow pan-cytokeratin stain
- CD68 indistinct or missing
- Cellular structure diffuse
Get results faster
Hyperion™ Imaging Systems use a one-step staining and detection approach that enables samples to be simultaneously stained, acquired and analyzed.
A one-step staining and detection workflow
Imaging Mass Cytometry enables 40-plus markers that can be simultaneously stained, acquired and visualized. Other fluorescence-based approaches involve iterative rounds of staining, imaging and removal of fluorescent signals. The IMC workflow is without sequential immunostaining approaches, multiple slide treatment rounds or acquisition steps.
Need to ship or store slides?
- All-at-once batch staining of all slides to reduce technical variation
- Acquire at any time from shipped and/or stored slides that have been stained
- Analyze previously banked tissue slides to be correlated to known clinical outcomes
Young Blood for Old Brains and the Quest to Slow Brain Aging | Tony Wyss-Coray, Ph.D., Stanford University
Mar 06 - Mar 09
50th ADF Conference (Dermatological Research Working Group) in Duesseldorf, Germany
Mar 09 - Mar 13
US HUPO 2024 (Human Proteome Organization) in Portland, OR
Mar 12 - Mar 13
1st German FlowCore Summit in Mainz, Germany
Mar 13 - Mar 15
Antimicrobial Resistance – Genomes, Big Data and Emerging Technologies in Hinxton, UK
Mar 13 - Mar 16
18th WRIM (World Immune Regulation Meeting) in Davos, Switzerland
Mar 14 - Mar 15
BSI (British Society for Immunology) Revealing and tackling the complexities of the tumour microenvironment in Birmingham, UK
Mar 18 - Mar 19
Spatial Biology UK 2024 in London, UK
Mar 19 - Mar 21
German Plant Breeding Conference 2024 in Geisenheim, Germany
Mar 21 - Mar 23
10th iTOC (Immunotherapy of Cancer) Conference in Munich, Germany
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