Cytometry Powered by Time-of-Flight: Igniting Insights into Immuno-Oncology. CyTOF Summit

CyTOF Summit 2022 is now available on demand

In this first installment of the CyTOF Summit, Standard BioTools™ brought together investigators from academia, pharma and biotech with a focus on oncology and immunology. These experts shared their clinically relevant research studies, data analysis approaches and technical applications.

The panel discussion portion of the Summit provided the opportunity for attendees to ask questions of these experts and learn more about how CyTOF® technology can support the research community.

Enjoy watching these presentations and discussions showcasing new findings in immuno-oncology and cancer research and learn tips and advice you can apply to your own research. 

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CyTOF Summit | Tuesday, June 14

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CyTOF summit Agenda


Welcome and Introduction
Technical Applications
High-Content Cytometry Solutions for Investigation, Discovery and Therapeutic Development in Immuno-Oncology

A brief overview of the use of CyTOF® technology to date in immuno-oncology, as well as an introduction of the newest products offered by Standard BioTools that are particularly relevant for the immuno-oncology field.

Roberto Spada

Roberto Spada, PhD

Standard BioTools

Customization of the Maxpar® Direct™ Immune Profiling Assay™ and Maxpar Pathsetter™ for Use in a Biotech Setting

Estrada discusses the significance of studying the proteome of single cells as a critical part of understanding and advancing immunotherapy studies and how the ease of customizing ready-to-use Standard BioTools immune profiling panels and workflows has sped time-to-answer for 2seventy bio.

Pedro Estrada

Pedro Estrada, MS

2seventy bio™

Simultaneous Quantification of Multiple Targets With Mass Cytometry to Support Biotherapeutic Drug Development

Stevens introduces an approach for simultaneous analysis of multiple cell surface drug target receptors in diverse cell populations based on deep immunophenotyping of human whole blood samples. This technique is being used in biotherapeutic development to inform modeling and simulation teams on target feasibility and coverage requirements at Pfizer.

Chad Stevens

Chad Stevens, MS

Pfizer Worldwide Research & Development
Research Presentations
Connecting Cells to Patient Outcomes

Irish presents his latest work on glioblastoma, focusing on contrasting immune microenvironments seen in glioblastoma tumor types that can be detected on MRI. He discusses the use of CyTOF as a great technique for quantifying and characterizing all of the cells that are present in the tissue, including key navigation, T cell subtyping, activation and memory, checkpoint and life and death markers that allow measurement of what correlates with treatment responses or prognostic signatures.

Jonathan Irish

Jonathan Irish, PhD

Vanderbilt University

An Unsupervised Learning Approach to Quantifying T Cell States From High-Plex Cytometry Data in Cancer Immunotherapy Clinical Trials

Cytometric studies surveying cell phenotypes often do not account for functional states of immune cells that occur along continuous phenotypic transitions. To overcome this limitation, Sidiropoulos explains how he and his team have applied single-cell trajectory inference and non-negative matrix factorization methods to CyTOF data to trace the dynamics of T cell states.

Dimitrios Sidiropoulos

Dimitrios Sidiropoulos, PhD Candidate

Johns Hopkins School of Medicine

Cellular Microenvironments in Stem Cell Niche Contacting Glioblastoma

Ihrie outlines how CyTOF has been particularly useful in dissecting the complex mix of cell types present in glioblastoma by enabling cell classification and how Imaging Mass Cytometry™ supports an understanding of cell interactions in the tumor microenvironment and furthers insights into the connection of tumor contact status with prognosis.

Rebecca Ihrie

Rebecca Ihrie, PhD

Vanderbilt University

Immune Correlates of GD2 CAR T Cell Expansion in Pediatric Osteosarcoma and Neuroblastoma Patients

Ramakrishna conducted a phase I trial (NCT02107963) to determine the feasibility of production and safety of administering escalating doses of GD2.Ox40.CD28.z chimeric antigen receptor T cells (GD2-CAR T) in children and young adults with neuroblastoma and osteosarcoma. She explains the robust GD2-CAR T expansion observed in half of the patients but limited persistence in all patients.

Sneha Ramakrishna

Sneha Ramakrishna, MD

Center for Cancer Cell Therapy, Stanford University School of Medicine


Panel Discussion
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